Equipe Neuropharmacologie Fonctionnelle

Thématiques Neuropharmacologie des gaz inertes : potentiel neuroprotecteur et mécanismes d'action Interactions cortico-limbiques dopamine-glutamate Personnels Responsable : Jacques H. ABRAINI, PR1, UCBN Chercheur(s) et enseignant(s)-chercheur(s) : Nathalie COLLOC'H, CR1, CNRS Hélène N. DAVID, NNOXe Pharmaceuticals Benoît HALAEWYN, NNOXe Pharmaceuticals

Publications majeures ou représentatives

• Colloc'h N, Sopkova-de Oliveira Santos J, Retailleau P, Vivares D, Bonnete F, Langlois d'Estainto B, Gallois B, Brisson A, Risso JJ, Lemaire M, Prange T, Abraini JH (2007) Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action. Biophys J 92:217-224.

• David HN, Ansseau M, Lemaire M, Abraini JH (2006) Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization. Biol Psychiatry 60:49-57.

• Abraini JH, David HN, Lemaire M (2005) Potentially neuroprotective and therapeutic properties of nitrous oxide and xenon. Ann N Y Acad Sci 1053:289-300.

• David HN, Leveille F, Chazalviel L, MacKenzie ET, Buisson A, Lemaire M, Abraini JH (2003) Reduction of ischemic brain damage by nitrous oxide and xenon. J Cereb Blood Flow Metab 23:1168-1173.

• Colloc'h N, Girard E, Dhaussy AC, Kahn R, Ascone I, Mezouar M, Fourme R (2006) High pressure macromolecular crystallography: the 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly. Biochim Biophys Acta 1764:391-397.