Physiopathologie de la SYnapse

Thématiques Neurotransmission glutamatergique : caractérisation et signalisation Neurotransmission glutamatergique et maladie d'Alzheimer Rôle des cellules gliales dans la neurotransmission glutamatergique Potentiel thérapeutique des antagonistes glutamatergiques dans la progression tumorale au sein du système nerveux central Personnels Responsable : Alain Buisson, Pr Université de Caen Chercheur(s) et enseignant(s)-chercheur(s) : Fréderic Mouriaux, PU-PH Université de Caen, CHU de Caen Olivier Nicole, Chargé de Recherche, CNRS

Publications majeures ou représentatives

• Calipel A, Mouriaux F, Glotin AL, Malecaze F, Faussat AM, Mascarelli F. (2006) Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. J Biol Chem. 281:9238-50.

• Lesne S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A (2005) NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci 25:9367-9377.

• Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF (2005) Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci 25:4319-4329.

• Nicole O, , Ali C, Docagne F, Plawinski L, MacKenzie E T, Vivien D and Buisson A. (2001) Neuroprotection mediated by glial cell line-derived neurotrophic factor : involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway, J. Neurosci 21: 3024-3033.

• Nicole O, Docagne F, ALI C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D and Buisson A. (2001) The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling, Nat Med 7:59-64.